Melatonin treatment improves adipose-derived mesenchymal stem cell therapy for acute lung ischemia-reperfusion injury.

@article{Yip2013MelatoninTI,
  title={Melatonin treatment improves adipose-derived mesenchymal stem cell therapy for acute lung ischemia-reperfusion injury.},
  author={Hon-Kan Yip and Yi-Chih Chang and Christopher Glenn Wallace and Li-Teh Chang and Tzu-hsien Tsai and Yung-Lung Chen and Hsueh-wen Chang and Steve Leu and Yen-yi Zhen and Ching-Yen Tsai and Kuo-Ho Yeh and Cheuk-Kwan Sun and Chia-Hung Yen},
  journal={Journal of pineal research},
  year={2013},
  volume={54 2},
  pages={
          207-21
        }
}
This study investigated whether melatonin-treated adipose-derived mesenchymal stem cells (ADMSC) offered superior protection against acute lung ischemia-reperfusion (IR) injury. Adult male Sprague-Dawley rats (n = 30) were randomized equally into five groups: sham controls, lung IR-saline, lung IR-melatonin, lung IR-melatonin-normal ADMSC, and lung IR-melatonin-apoptotic ADMSC. Arterial oxygen saturation was lowest in lung IR-saline; lower in lung IR-melatonin than sham controls, lung IR… CONTINUE READING
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