Melatonin transport into mitochondria

@article{Mayo2017MelatoninTI,
  title={Melatonin transport into mitochondria},
  author={Juan Carlos Mayo and Rosa Mar{\'i}a Sainz and Pedro Gonzalez-Menendez and David Hevia and Rafael Cernuda-Cernuda},
  journal={Cellular and Molecular Life Sciences},
  year={2017},
  volume={74},
  pages={3927-3940}
}
Melatonin is a well-known, nighttime-produced indole found in bacteria, eukaryotic unicellulars, animals or vascular plants. In vertebrates, melatonin is the major product of the pineal gland, which accounts for its increase in serum during the dark phase, but it is also produced by many other organs and cell types. Such a wide distribution is consistent with its multiple and well-described functions which include from the circadian regulation and adaptation to seasonal variations to… Expand
Melatonin Uptake by Cells: An Answer to Its Relationship with Glucose?
TLDR
The major goal of the present review is to discuss the data and experiments that have addressed the relationship between the indole and glucose, and the molecular components underlying the regulatory actions of melatonin on insulin secretion in pancreatic beta-cells, mainly involving membrane receptors MTNR1A/B. Expand
Mitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions
TLDR
Melatonin is optimally positioned to scavenge the radicals and reduce the degree of oxidative damage, and in light of the “free radical theory of aging”, high melatonin levels in mitochondria would be expected to protect against age-related organismal decline. Expand
Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care
TLDR
Molecular pathways in which melatonin is considered a master regulator, with attention to cell death and inflammation mechanisms from basic, translational and clinical points of view in the context of newborn care are summarized. Expand
Advances in Characterizing Recently-Identified Molecular Actions of Melatonin: Clinical Implications
TLDR
The association of melatonin with mitochondria, because of its ability to inhibit oxidative stress, is very fortuitous since these organelles are a major site of damaging reactive oxygen species generation. Expand
Exosomes and Melatonin: Where Their Destinies Intersect
Cell-to-cell communication is a broad and complex process associated with regular stimuli to maintain healthy cell interactions. One of the agents capable of cellular communication is known as anExpand
Extended Signaling by Melatonin. Cell Cellular Lif Sci J 2018, 3(2): 000123
The whole spectrum of melatonin’s actions cannot be directly deduced from its primary signaling via its membranebound G protein-coupled receptors. This is not so much a matter of possibly existingExpand
An Examination of the Putative Role of Melatonin in Exosome Biogenesis
TLDR
The role and potential significance of melatonin in determining the efflux capacity of cells via the exosomal pathway is addressed and the clarification of the interplay between melatonin and exosome biogenesis and cargo sorting at the molecular level will help to define a cell’s secretion capacity. Expand
Involvement of Melatonin in the Regulation of the Circadian System in Crayfish
TLDR
Evidence is described that suggests that the rhythmic release of MEL contributes to the reinforcement of the temporal organization of nocturnal or diurnal circadian oscillators, and how MEL might coordinate functions that converge in the performance of complex behaviors. Expand
Melatonin — More than Just a Pineal Hormone
TLDR
The aim of this mini review is to sharpen the awareness of researchers towards the multiple sites of melatonin formation and the consequences thereof. Expand
Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases
TLDR
It is proposed that melatonin’s function as a glycolytic explains its actions in inhibiting a variety of diseases and the common denominator is melatonin's action in switching the metabolic phenotype of cells. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 195 REFERENCES
Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential
TLDR
PEPT1/2 can potentially be used as a cancer cell‐targeted melatonin delivery system to improve the therapeutic effects of melatonin in cancer treatment and play a pivotal role in melatonin uptake in cells. Expand
Extrapineal melatonin: sources, regulation, and potential functions
TLDR
The presence of melatonin in extrapineal organs, tissues, and fluids of mammals including humans is emphasized and information related to its peripheral production and regulation of this ubiquitously acting indoleamine is compiled. Expand
Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer
TLDR
It is demonstrated that members of the SLC2/GLUT family glucose transporters have a central role in melatonin uptake and is the first time that a facilitated transport of melatonin is suggested. Expand
Melatonin and mitochondrial function.
TLDR
Melatonin preserves the integrity of the mitochondria and helps to maintain cell functions and survival and may explain, at least in part, the protective properties found for the indoleamine in degenerative conditions such as aging. Expand
Melatonin biosynthesis in the thymus of humans and rats
TLDR
It is demonstrated in humans and rats that thymus contains melatonin, expresses the mRNAs encoding N-acetyltransferase and hydroxyindol-O-methyltransferase, the two key enzymes of the melatonin synthesis, and has this biosynthetic machinery activated. Expand
The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives.
TLDR
The findings from experimental models of numerous diseases overwhelming confirm that this indoleamine would likely have great benefit in aiding humans suffering with conditions that have as their basis tissue and molecular damage resulting from oxygen and nitrogen-based reactants. Expand
Occurrence and comparative physiology of melatonin in evolutionary diverse organisms
TLDR
Melatonin-related metabolic pathways conserved throughout evolution are examined, and the biological action of melatonin and related metabolites in the transduction of light and temperature signals, regulation of time-dependent processes, and in the trapping of free radicals for photoprotection are compared. Expand
Melatonin: an ancient molecule that makes oxygen metabolically tolerable
TLDR
It is hypothesized that the initial and primary function of melatonin in photosynthetic cyanobacteria, which appeared on Earth 3.5–3.2 billion years ago, was as an antioxidant and that the melatonin‐synthesizing actions of the engulfed bacteria were retained when these organelles became mitochondria and chloroplasts, respectively. Expand
Melatonin: reproductive effects.
TLDR
When melatonin is continuously available (from a subcutaneous deposit) it counteracts the antigonadotrophic influence of the pineal gland in light restricted or blinded hamsters, i.e., it causes a "functional pinealectomy". Expand
Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.
TLDR
Melatonin's functions as an antioxidant include: a), direct free radical scavenging, b), stimulation of antioxidative enzymes, c), increasing the efficiency of mitochondrial oxidative phosphorylation and reducing electron leakage (thereby lowering free radical generation), and 3), augmenting the efficiencyof other antioxidants. Expand
...
1
2
3
4
5
...