Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid-related orphan receptor.

@article{Lardone2011MelatoninSB,
  title={Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid-related orphan receptor.},
  author={Patricia Judith Lardone and Juan M. Guerrero and Jos{\'e} Mar{\'i}a Fern{\'a}ndez-Santos and A. Villagr{\'a} Rubio and In{\'e}s Mart{\'i}n-Lacave and Antonio Carrillo-Vico},
  journal={Journal of pineal research},
  year={2011},
  volume={51 4},
  pages={454-62}
}
Melatonin modulates a wide array of physiological events with pleiotropic effects on the immune system. While the relevance of specific melatonin membrane receptors has been well established for several biological functions, retinoic acid-related orphan receptor alpha (RORα) has been suggested as a mediator of nuclear melatonin signalling by results obtained from pharmacological approaches. However, a melatonin-mediated downstream effect cannot be ruled out, and further evidence is needed to… CONTINUE READING
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