Melatonin suppresses cyclosporine A-induced autophagy in rat pituitary GH3 cells.

Abstract

Cyclosporine A (CsA) is a powerful immunosuppressive drug with side effects including the induction of chronic nephrotoxicity including endoplasmic reticulum (ER) stress in tubular cells. Recently, it was reported that autophagy is induced by ER stress and serves to alleviate the associated deleterious effects. In the current study, CsA treatment (0-100… (More)
DOI: 10.1111/j.1600-079X.2010.00744.x

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