Melatonin stimulates HSP27 phosphorylation in human pancreatic carcinoma cells (PANC-1).

@article{LejaSzpak2007MelatoninSH,
  title={Melatonin stimulates HSP27 phosphorylation in human pancreatic carcinoma cells (PANC-1).},
  author={Anna Leja-Szpak and Jolanta Jaworek and Joanna Szklarczyk and Stanisław Jan Konturek and Wieslaw W. Pawlik},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2007},
  volume={58 Suppl 3},
  pages={177-88}
}
UNLABELLED Heat shock protein 27 (HSP27) is a cytoprotective chaperone, activated by stressful stimuli. HSP27 modulates aggregation and degradation of many proteins. Recent evidence suggests that HSP27 could be involved in the progression of tumor growth and in the development of resistance of various tumors to chemo- and radiotherapy. It has been reported that melatonin protects pancreatic cells and various tissues against inflammatory damage. Previous experimental studies have shown that… CONTINUE READING

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