Melatonin stabilises sleep onset time in a blind man without entrainment of cortisol or temperature rhythms

@article{Folkard1990MelatoninSS,
  title={Melatonin stabilises sleep onset time in a blind man without entrainment of cortisol or temperature rhythms},
  author={Simon Folkard and Jos{\'e}phine Arendt and M. E. Aldhous and H. Kennett},
  journal={Neuroscience Letters},
  year={1990},
  volume={113},
  pages={193-198}
}

Melatonin and Sleep

TLDR
Large-scale, randomized, placebo-controlled clinical trials in insomnia patients aged 55 years and older indicated that PRM given for 3 weeks or more improved sleep quality, facilitated sleep onset and improved morning alertness, daytime functioning and quality of life and reduced hypnotic drug usage.

ENTRAINMENT OF FREE-RUNNING CIRCADIAN RHYTHMS BY MELATONIN IN BLIND PEOPLE

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Administration of melatonin can entrain circadian rhythms in most blind people who have free-running rhythms, and in six of the seven subjects the rhythm was entrained to a 24.0-hour cycle during melatonin treatment.

Entrainment of free-running circadian rhythms by melatonin in blind people.

TLDR
Administration of melatonin can entrain circadian rhythms in most blind people who have free-running rhythms, and in six of the seven subjects the rhythm was entrained to a 24.0-hour cycle during melatonin treatment.

MELATONIN AND CIRCADIAN SLEEP DISORDERS

TLDR
In field and simulated studies of jet lag and shift work suitably timed melatonin improved sleep and hastened readaptation of the circadian rhythms following the phase shift, and improved a number of sleep parameters in blind subjects suffering from non-24-hour sleep wake disorder.

Complex Effects of Melatonin on Human Circadian Rhythms in Constant Dim Light

TLDR
Results indicate that melatonin was able to phase shift sleep and core temperature but was unable to synchronize core temperature consistently, and in the majority of subjects, the sleep-wake cycle could be synchronized.

Melatonin administration can entrain the free-running circadian system of blind subjects.

TLDR
Results show for the first time that daily melatonin administration can entrain free-running circadian rhythms in some blind subjects assessed using reliable physiological markers of the circadian system.

Circadian Rhythm Sleep Disorders

TLDR
Melatonin, given several hours before its endogenous peak at night, effectively advances sleep time in DSPS and adjusts the sleep-wake cycle to 24 hours in blind individuals, and melatonin replacement therapy may provide a rational approach to the treatment of age-related insomnia in the elderly.

Melatonin Administration to Blind People: Phase Advances and Entrainment

TLDR
The purpose of this study was to test the phase-shifting and entraining effects of melatonin in human subjects, and found five totally blind men found to have free-running endogenous melatonin rhythms to be remarkably stable.

Use of melatonin in circadian rhythm disorders and following phase shifts.

TLDR
Findings suggest that melatonin is of benefit in facilitating adaptation to forced phase shifts and in conditions of circadian rhythm disturbance.

Treatment of circadian rhythm disorders--melatonin.

TLDR
While melatonin is useful in well-controlled conditions, the indiscriminate use of unlicensed preparations is not advisable and performance effects and changes in sleep architecture need to be fully evaluated.
...

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