Melatonin response to clonidine administration in depression: indication of presynaptic alpha2-adrenoceptor dysfunction.

@article{Paparrigopoulos2001MelatoninRT,
  title={Melatonin response to clonidine administration in depression: indication of presynaptic alpha2-adrenoceptor dysfunction.},
  author={Thomas J. Paparrigopoulos and Constantinos Psarros and J D Bergiannaki and Eleytheria Varsou and Urania Dafni and C. Stefanis},
  journal={Journal of affective disorders},
  year={2001},
  volume={65 3},
  pages={307-13}
}
BACKGROUND The aim of this study was to investigate alpha2-adrenoceptor sensitivity in depression, by using melatonin response to clonidine administration as an index of alpha2-adrenoceptor functioning. METHOD 35 depressed subjects and 41 healthy controls were assessed for overnight urinary melatonin pre- and post-administration of oral clonidine. RESULTS Administration of clonidine significantly reduced melatonin concentrations in depressed patients but not in control subjects… CONTINUE READING