Melatonin regulation of antioxidant enzyme gene expression

  title={Melatonin regulation of antioxidant enzyme gene expression},
  author={Juan C Mayo and Rosa M S{\'a}inz and Isaac Antol{\'i}n and Federico Herrera and Virginie Martin and Carmen Mart{\'i}n Rodr{\'i}guez},
  journal={Cellular and Molecular Life Sciences CMLS},
Antioxidant enzymes (AOEs) are part of the primary cellular defense against free radicals induced by toxins and/or spontaneously formed in cells. Melatonin (MLT) has received much attention in recent years due to its direct free radical scavenging and antioxidant properties. In the present work we report that MLT, at physiological serum concentrations (≈ 1 nM), increases the mRNA of both superoxide dismutases (SODs) and glutathione peroxidase (GPx) in two neuronal cell lines. The MLT effect on… CONTINUE READING


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