Melatonin regulates the phosphorylation of CREB in ovine pars tuberalis.

  title={Melatonin regulates the phosphorylation of CREB in ovine pars tuberalis.},
  author={Shaun McNulty and Alexander W. Ross and Perry Barrett and Michael H Hastings and P Jeffrey Morgan},
  journal={Journal of neuroendocrinology},
  volume={6 5},
This study investigated whether melatonin could modulate the phosphorylation of the calcium/cyclic AMP response-element binding-protein (CREB) within primary cell cultures of ovine pars tuberalis (oPT) and pars distalis (oPD). Gel shift assays confirmed the presence of nuclear factors able to alter the electrophoretic mobility of a 32P-labelled CRE oligonucleotide. Two shifted bands were observed probably due to monomer and dimer binding to the CRE. Each band was supershifted by antisera… CONTINUE READING


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