Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain

@article{Yon2006MelatoninRT,
  title={Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain},
  author={Jun-Heum Yon and Lisa B. Carter and Russell J Reiter and Vesna Jevtovi{\'c}-Todorovi{\'c}},
  journal={Neurobiology of Disease},
  year={2006},
  volume={21},
  pages={522-530}
}
General anesthetics cause widespread apoptotic neurodegeneration in many regions of the developing rat brain. The activation of mitochondria-dependent apoptotic pathway is important in the early stages of anesthesia-induced developmental neuroapoptosis. To investigate potential means of protecting against this type of damage, we studied melatonin, a sleep-promoting agent and antioxidant known to inhibit apoptotic-type neuronal damage by improving mitochondrial homeostasis and stabilizing the… CONTINUE READING

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