Melatonin reduces the oxidation of nuclear DNA and membrane lipids induced by the carcinogen delta-aminolevulinic acid.

@article{Karbownik2000MelatoninRT,
  title={Melatonin reduces the oxidation of nuclear DNA and membrane lipids induced by the carcinogen delta-aminolevulinic acid.},
  author={Małgorzata Karbownik and D X Tan and Russell J Reiter},
  journal={International journal of cancer},
  year={2000},
  volume={88 1},
  pages={7-11}
}
Well known are the anti-oxidant, free radical-scavenging and anti-tumorigenic properties of melatonin. delta-Aminolevulinic acid (ALA) is a precursor of heme synthesis. When over-produced and accumulated in tissues, ALA is a potential carcinogen, such as in the course of acute intermittent porphyria, hereditary tyrosinemia and lead poisoning. Our aim was to… CONTINUE READING