Melatonin reduces lung oxidative stress in patients with chronic obstructive pulmonary disease: a randomized, double‐blind, placebo‐controlled study

@article{deMatosCavalcante2012MelatoninRL,
  title={Melatonin reduces lung oxidative stress in patients with chronic obstructive pulmonary disease: a randomized, double‐blind, placebo‐controlled study},
  author={Antonio George de Matos Cavalcante and Pedro Felipe Carvalhedo de Bruin and Veralice Meireles Sales de Bruin and Deuzilane Muniz Nunes and Eanes Delgado Barros Pereira and Marina Medeiros Cavalcante and Geanne Matos de Andrade},
  journal={Journal of Pineal Research},
  year={2012},
  volume={53}
}
Abstract:  Chronic obstructive pulmonary disease (COPD), a major cause of death and disability, is attributed to an abnormal inflammatory response by the lungs to noxious substances, primarily from cigarette smoke. Although oxidative stress is regarded as central to the pathogenesis of COPD, very few studies have examined the effects of antioxidants in this condition. This was a randomized, double‐blind, placebo‐controlled study on the effects of melatonin in COPD. Thirty‐six consecutive… 
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The effectiveness of various antioxidant factors in COPD and their potential beneficial effect in the treatment of the disease are reviewed.
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The body of knowledge on melatonin’s efficacy in respiratory diseases is encouraging for the use of this powerful agent in COVID-19, and the body of evidence on protective effects in other respiratory dysfunctions is recalled.
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Some of the most widely used therapeutics that affect the root cause of aging and oxidative stress (metformin, melatonin, sirolimus, statins, vitamin D, and testosterone) in context of COPD therapy are described and discussed.
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