Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis.

@article{Maity2009MelatoninRI,
  title={Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis.},
  author={Pallab Maity and Samik Bindu and Sumanta Dey and Manish Kumar Goyal and Athar Alam and Chinmay Pal and Russell J Reiter and Uday Bandyopadhyay},
  journal={Journal of pineal research},
  year={2009},
  volume={46 3},
  pages={314-23}
}
Augmentation of gastric mucosal cell apoptosis due to development of oxidative stress is one of the main pathogenic events in the development of nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy. Identification of a nontoxic, anti-apoptotic molecule is warranted for therapy against NSAID-induced gastropathy. The objective of the present study was to define the mechanism of the anti-apoptotic effect of melatonin, a nontoxic molecule which scavenges reactive oxygen species. Using an… CONTINUE READING