Melatonin reduces dimethylnitrosamine-induced liver fibrosis in rats.

@article{Tahan2004MelatoninRD,
  title={Melatonin reduces dimethylnitrosamine-induced liver fibrosis in rats.},
  author={Veysel Tahan and Reşat Ozaras and Billur Ikbal Canbakan and Hafize Uzun and S. Gizem Aydin and Beytullah Yildirim and Huseyin Aytekin and Gulsen Ozbay and A. A. Mert and Hakan Şenturk},
  journal={Journal of pineal research},
  year={2004},
  volume={37 2},
  pages={78-84}
}
Increased deposition of the extracellular matrix components, particularly collagen, is a central phenomenon in liver fibrosis. Stellate cells, the central mediators in the pathogenesis of fibrosis are activated by free radicals, and synthesize collagen. Melatonin is a potent physiological scavenger of hydroxyl radicals. Melatonin has also been shown to be involved in the inhibitory regulation of collagen content in tissues. At present, no effective treatment of liver fibrosis is available for… CONTINUE READING
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