Melatonin receptors: molecular biology of a new family of G protein-coupled receptors.

Abstract

A family of high-affinity, G protein-coupled receptors for the pineal hormone melatonin has been cloned from vertebrates. These recombinant receptors exhibits similar affinity and pharmacological characteristics to each other and to endogenous receptors, as defined with the melatonin agonist 2-[125I]iodomelatonin (125I-Mel). Two mammalian melatonin receptor… (More)

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