Melatonin receptor signaling: finding the path through the dark.

  title={Melatonin receptor signaling: finding the path through the dark.},
  author={Monica I. Masana and Margarita L Dubocovich},
  journal={Science's STKE : signal transduction knowledge environment},
  volume={2001 107},
Melatonin, dubbed "the hormone of darkness," is involved in relaying photoperiodic information to the organism. Not only is melatonin involved in the regulation of circadian rhythms and sleep, but it also has roles in visual, cerebrovascular, reproductive, neuroendocrine, and neuroimmunological functions. Melatonin mediates its effects through G protein-coupled receptors: MT(1), MT(2), and, possibly, MT(3). Pharmacological agents have been instrumental in identifying these receptor types… CONTINUE READING

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