Melatonin provokes cell death in human B-lymphoma cells by mitochondrial-dependent apoptotic pathway activation.

@article{Trubiani2005MelatoninPC,
  title={Melatonin provokes cell death in human B-lymphoma cells by mitochondrial-dependent apoptotic pathway activation.},
  author={Oriana Trubiani and Rina Recchioni and Fausto Moroni and Jacopo Pizzicannella and Sergio Caputi and Roberto Di Primio},
  journal={Journal of pineal research},
  year={2005},
  volume={39 4},
  pages={425-31}
}
Apoptosis is an important cell suicide programme involved in physiological and pathological processes. Apoptosis can be induced in different ways depending on cell type and acquired signal. Melatonin, the major secretory product of the pineal gland, participates in many important physiological functions and displays a remarkable functional versatility exhibiting antioxidant, oncostatic, anti-aging, and immunomodulatory properties. Recently, it has been shown that, in addition to pineal gland… CONTINUE READING