Melatonin provides neuroprotection in the late-gestation fetal sheep brain in response to umbilical cord occlusion.

@article{Miller2005MelatoninPN,
  title={Melatonin provides neuroprotection in the late-gestation fetal sheep brain in response to umbilical cord occlusion.},
  author={Suzanne L Miller and Edwin Bingbing Yan and Margie Castillo-Mel{\'e}ndez and Graham Jenkin and David W Walker},
  journal={Developmental neuroscience},
  year={2005},
  volume={27 2-4},
  pages={
          200-10
        }
}
Oxygen free radicals, including the highly toxic hydroxyl radical (*OH), initiate lipid peroxidation and DNA/RNA fragmentation and damage cells. The pineal hormone melatonin is an antioxidant and powerful scavenger of *OH. We hypothesized that maternally administered melatonin could reduce *OH formation, lipid peroxidation, and DNA/RNA damage in the fetal brain in response to asphyxia. In 15 fetal sheep, extracellular *OH was measured by microdialysis in white and gray matter of the… CONTINUE READING
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