Melatonin protects hepatic mitochondrial respiratory chain activity in senescence-accelerated mice.

@article{Okatani2002MelatoninPH,
  title={Melatonin protects hepatic mitochondrial respiratory chain activity in senescence-accelerated mice.},
  author={Yuji Okatani and Akihiko Wakatsuki and Russell J Reiter},
  journal={Journal of pineal research},
  year={2002},
  volume={32 3},
  pages={143-8}
}
Mitochondrial oxidative damage from free radicals may be a factor underlying aging, and melatonin, a powerful free radical scavenger, may participate in mitochondrial metabolism. We measured respiratory chain complex I and IV activities in liver mitochondria from a strain of senescence-accelerated prone mice (SAMP8) and a strain of senescence-accelerated resistant mice (SAMR1) at age 3, 6, and 12 months. No age-associated effects were found in either complex I and IV activities, thiobarbituric… CONTINUE READING
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