Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical.

@article{Bandyopadhyay2000MelatoninPA,
  title={Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical.},
  author={Debashis Bandyopadhyay and K. Biswas and Uday Bandyopadhyay and Russell J Reiter and Ranajit K. Banerjee},
  journal={Journal of pineal research},
  year={2000},
  volume={29 3},
  pages={143-51}
}
The antiulcer effect of melatonin on gastric lesions caused by restraint-cold stress or by indomethacin (IMN) was studied with the intent of determining the mechanism of action of the indole. Melatonin dose-dependently prevents both stress and IMN-induced gastric damage with around 90% inhibition at a dose of 60 mg per kg BW. When compared with already-marketed antiulcer drugs, such as ranitidine and omeprazole, melatonin was found to be more effective than ranitidine but less effective than… CONTINUE READING