Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease

@article{Patki2011MelatoninPA,
  title={Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease},
  author={Gaurav Patki and Y. Alfred Lau},
  journal={Pharmacology Biochemistry and Behavior},
  year={2011},
  volume={99},
  pages={704-711}
}
Neuronal oxidative stress and mitochondrial dysfunction have been implicated in Parkinson's disease. Melatonin is a natural antioxidant and free radical scavenger that has been shown to effectively reduce cellular oxidative stress and protect mitochondrial functions in vitro. However, whether melatonin is capable of slowing down the neurodegenerative process in animal models of Parkinson's disease remains controversial. In this research, we examined long-term melatonin treatment on striatal… CONTINUE READING

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