Melatonin protects against methotrexate‐induced memory deficit and hippocampal neurogenesis impairment in a rat model

@article{Sirichoat2019MelatoninPA,
  title={Melatonin protects against methotrexate‐induced memory deficit and hippocampal neurogenesis impairment in a rat model},
  author={Apiwat Sirichoat and Suchada Krutsri and Kornrawee Suwannakot and Anusara Aranarochana and Pornthip Chaisawang and Wanassanun Pannangrong and Peter M. Wigmore and Jariya Umka Welbat},
  journal={Biochemical Pharmacology},
  year={2019},
  volume={163},
  pages={225–233}
}
Graphical abstract Figure. No caption available. &NA; Methotrexate (MTX) is a chemotherapy agent linked to cognitive deficits in cancer patients received chemotherapy treatment. MTX decreases cell proliferation in the hippocampus, which is concomitant with cognitive deficits in animal models. The present study aimed to investigate the disadvantages of MTX on cognition associated with cell division, survival, and immature neurons involved in hippocampal neurogenesis, as well as the practical… Expand
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