Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening.

@article{Petrosillo2009MelatoninPA,
  title={Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening.},
  author={Giuseppe Petrosillo and Giuseppe Colantuono and Nicola Moro and Francesca Maria Ruggiero and Edy Altea Tiravanti and Nicola Di Venosa and Tommaso Fiore and Giuseppe Paradies},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2009},
  volume={297 4},
  pages={H1487-93}
}
Melatonin, a well-known antioxidant, has been shown to protect against ischemia-reperfusion myocardial damage. Mitochondrial permeability transition pore (MPTP) opening is an important event in cardiomyocyte cell death occurring during ischemia-reperfusion and therefore a possible target for cardioprotection. In the present study, we tested the hypothesis that melatonin could protect heart against ischemia-reperfusion injury by inhibiting MPTP opening. Isolated perfused rat hearts were… CONTINUE READING

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