Melatonin protects against gentamicin-induced nephrotoxicity in rats.

  title={Melatonin protects against gentamicin-induced nephrotoxicity in rats.},
  author={G{\"o}ksel Şener and Ahmet Ozer Sehirli and Hale Z Altunbas and Yasemin Ersoy and K{\"u}bra Paskaloğlu and Serap Arbak and G{\"u}l Ayanoglu-Dulger},
  journal={Journal of pineal research},
  volume={32 4},
Acute renal failure is a major complication of gentamicin (GEN), which is widely used in the treatment of gram-negative infections. A large body of in vitro and in vivo evidence indicates that reactive oxygen metabolites (or free radicals) are important mediators of gentamicin nephrotoxicity. In this study we investigated the role of free radicals in gentamicin-induced nephrotoxicity and whether melatonin, a potent antioxidant could prevent it. For this purpose female Sprague-Dawley rats were… CONTINUE READING


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