Melatonin prevents methotrexate‐induced hepatorenal oxidative injury in rats

  title={Melatonin prevents methotrexate‐induced hepatorenal oxidative injury in rats},
  author={Nermina Jahovic and H{\"u}lya Çevik and Ahmet Ozer Sehirli and Berrak Ç. Yeğen and G{\"o}ksel Şener},
  journal={Journal of Pineal Research},
Abstract:  Regarding the mechanisms of methotrexate (MTX) hepatotoxicity and nephrotoxicity, several hypotheses have been put forward, among which oxidative stress (including depletion of glutathione) is likely. This investigation elucidates the role of free radicals in MTX‐induced toxicity and the protection by melatonin. Wistar albino rats were injected with MTX intraperitoneally. Following a single dose of MTX (20 mg/kg), either saline (MTX group) or melatonin (10 mg/kg, MTX + Mel group) was… 

Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

Melatonin has the potential to reduceMTX induced oxidative stress, neutrophil infiltration as well as renal damage and is suggested that melatonin may be beneficial in minimizing MTX induced renal damage in humans.

Vitamin C attenuates methotrexate-induced oxidative stress in kidney and liver of rats.

From the results of this study, it is observed that Vit C administration modulates the antioxidant redox system and reduces the renal and hepatic oxidative stress induced by MTX.

Protective Effects of Exogenous Melatonin Against Methotrexate-Induced Intestinal Injury

It is demonstrated that supplementation by exogenous melatonin significantly reduces MTX-induced small intestinal damage, indicating that it may be beneficial in ameliorating MTx-induced enteritis in humans.

Ellagic acid as a potential antioxidant, alleviates methotrexate-induced hepatotoxicity in male rats

The hypothesis that EA may be used as a promising pre-therapy to prevent the MIH is supported, as the remarkable protective effect of EA on liver has been confirmed by histological examination.

Rutin ameliorates methotrexate induced hepatic injury in rats.

Rutin may be a potential adjuvant drug to reduce the hepatic side effects observed during Mtx therapy for various clinical conditions.

Quercetin ameliorates methotrexate-induced renal damage, apoptosis and oxidative stress in rats

In conclusion, renal toxic effects of MTX may be alleviated by QE, which significantly suppressed MDA level, compensated deficits in the anti-oxidant defenses in kidney tissue resulted from MTX administration.

Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.

Administration of curcumin once daily for 5 consecutive days after MTX challenge mitigated the injurious effects of MTX and ameliorated all the altered biochemical parameters, indicating thatCurcumin may be of therapeutic benefit against MTX-cytotoxicity.

Methotrexate-induced renal oxidative stress in rats: the role of a novel antioxidant caffeic acid phenethyl ester

Investigation of the role of caffeic acid phenethyl ester (Caffeic Ester), a novel antioxidant, on methotrexate-induced renal oxidative stress in rats found that it leads to a reduction in antioxidant enzymatic defense capacity and causes lipid peroxidation in renal tissue.

Effects of quercetin on methotrexate-induced nephrotoxicity in rats

As a result, Mtx administration may involve oxidative stress by causing structural and functional damage in kidney tissue in rats and quercetin may be promising to alleviate Mtx-induced renal toxicity.



Melatonin protects against gentamicin‐induced nephrotoxicity in rats

The significant decrease in GSH and increases in MDA levels, PO and MPO activity indicated that GEN‐induced tissue injury was mediated through oxidative reactions, and simultaneous melatonin administration protected kidney tissue against the oxidative damage and the nephrotoxic effect caused by GEN treatment.

Glutamine Enhances Selectivity of Chemotherapy Through Changes in Glutathione Metabolism

It is suggested that oral glutamine supplementation will enhance the selectivity of antitumor drugs by protecting normal tissues from and possibly sensitizing tumor cells to chemotherapy treatment-related injury.

Vitamin E protects intestinal basolateral membrane from CMF-induced damages in rat.

The membrane cholesterol and phospholipid levels which were altered in CMF treated rats were bought back to the normal in co-administration of vitamin E, and the enzyme activities were found to be restored with concomitant reduction in malondialdehyde levels and an increase in the sulfhydryl groups.

Hepatotoxicity in a rat model caused by orally administered methotrexate

This is the first experimental model in which oral methotrexate administration has been associated with hepatotoxicity, and further development of this model should provide valuable insights into the pathogenesis of metotrexate hepatot toxicity.

Folinic acid protects against suppression of growth by methotrexate in mice.

It can be deduced that patients suffering from juvenile rheumatoid arthritis or acute lymphoblastic leukaemia receiving MTX over a long period of time might be at a risk of experiencing short-term suppression of growth, however they could benefit from supplementation with folinic acid.

Protection effects of procaine on oxidative stress and toxicities of renal cortical slices from rats caused by cisplatin in vitro

The results suggest that depletion of GSH might be a determinant step in the oxidative stress and subsequent cytotoxicity, and that procaine is a powerful antioxidant and would be a promising drug for ameliorating some of the adverse effects of CDDP.

Methotrexate: pentose cycle and oxidative stress

The net results appear to show that the biological situation resulting from treatment with MTX leads to a reduction of effectiveness of the antioxidant enzyme defence system.