Melatonin prevents methotrexate‐induced hepatorenal oxidative injury in rats

@article{Jahovic2003MelatoninPM,
  title={Melatonin prevents methotrexate‐induced hepatorenal oxidative injury in rats},
  author={Nermina Jahovic and H{\"u}lya Çevik and Ahmet Ozer Sehirli and Berrak Ç. Yeğen and G{\"o}ksel Şener},
  journal={Journal of Pineal Research},
  year={2003},
  volume={34}
}
Abstract:  Regarding the mechanisms of methotrexate (MTX) hepatotoxicity and nephrotoxicity, several hypotheses have been put forward, among which oxidative stress (including depletion of glutathione) is likely. This investigation elucidates the role of free radicals in MTX‐induced toxicity and the protection by melatonin. Wistar albino rats were injected with MTX intraperitoneally. Following a single dose of MTX (20 mg/kg), either saline (MTX group) or melatonin (10 mg/kg, MTX + Mel group) was… Expand
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