Melatonin prevents methotrexate‐induced hepatorenal oxidative injury in rats

@article{Jahovic2003MelatoninPM,
  title={Melatonin prevents methotrexate‐induced hepatorenal oxidative injury in rats},
  author={Nermina Jahovic and H{\"u}lya Çevik and Ahmet Ozer Sehirli and Berrak Ç. Yeğen and G{\"o}ksel Şener},
  journal={Journal of Pineal Research},
  year={2003},
  volume={34}
}
Abstract:  Regarding the mechanisms of methotrexate (MTX) hepatotoxicity and nephrotoxicity, several hypotheses have been put forward, among which oxidative stress (including depletion of glutathione) is likely. This investigation elucidates the role of free radicals in MTX‐induced toxicity and the protection by melatonin. Wistar albino rats were injected with MTX intraperitoneally. Following a single dose of MTX (20 mg/kg), either saline (MTX group) or melatonin (10 mg/kg, MTX + Mel group) was… 

Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

Melatonin has the potential to reduceMTX induced oxidative stress, neutrophil infiltration as well as renal damage and is suggested that melatonin may be beneficial in minimizing MTX induced renal damage in humans.

Vitamin C attenuates methotrexate-induced oxidative stress in kidney and liver of rats.

From the results of this study, it is observed that Vit C administration modulates the antioxidant redox system and reduces the renal and hepatic oxidative stress induced by MTX.

Protective Effects of Exogenous Melatonin Against Methotrexate-Induced Intestinal Injury

It is demonstrated that supplementation by exogenous melatonin significantly reduces MTX-induced small intestinal damage, indicating that it may be beneficial in ameliorating MTx-induced enteritis in humans.

Ellagic acid as a potential antioxidant, alleviates methotrexate-induced hepatotoxicity in male rats

The hypothesis that EA may be used as a promising pre-therapy to prevent the MIH is supported, as the remarkable protective effect of EA on liver has been confirmed by histological examination.

Rutin ameliorates methotrexate induced hepatic injury in rats.

Rutin may be a potential adjuvant drug to reduce the hepatic side effects observed during Mtx therapy for various clinical conditions.

Quercetin ameliorates methotrexate-induced renal damage, apoptosis and oxidative stress in rats

In conclusion, renal toxic effects of MTX may be alleviated by QE, which significantly suppressed MDA level, compensated deficits in the anti-oxidant defenses in kidney tissue resulted from MTX administration.

Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.

Administration of curcumin once daily for 5 consecutive days after MTX challenge mitigated the injurious effects of MTX and ameliorated all the altered biochemical parameters, indicating thatCurcumin may be of therapeutic benefit against MTX-cytotoxicity.

Methotrexate-induced renal oxidative stress in rats: the role of a novel antioxidant caffeic acid phenethyl ester

Investigation of the role of caffeic acid phenethyl ester (Caffeic Ester), a novel antioxidant, on methotrexate-induced renal oxidative stress in rats found that it leads to a reduction in antioxidant enzymatic defense capacity and causes lipid peroxidation in renal tissue.

Effects of quercetin on methotrexate-induced nephrotoxicity in rats

As a result, Mtx administration may involve oxidative stress by causing structural and functional damage in kidney tissue in rats and quercetin may be promising to alleviate Mtx-induced renal toxicity.
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