Melatonin prevents hydrogen peroxide-induced Bax expression in cultured rat astrocytes.

@article{Juknat2005MelatoninPH,
  title={Melatonin prevents hydrogen peroxide-induced Bax expression in cultured rat astrocytes.},
  author={Adela Ana Juknat and Maria M{\'e}ndez and Ana Quaglino and Cecilia Irene Fameli and Marcela Mena and M L Kotler},
  journal={Journal of pineal research},
  year={2005},
  volume={38 2},
  pages={84-92}
}
During oxidative stress, cell apoptosis is promoted through the mitochondrial death pathway. Increased reactive oxygen species (ROS) are linked to excess cell loss and mediate the induction of apoptosis in various cell types. However, the role of ROS in the apoptotic pathway has not been clearly established. The aims of this study were to investigate the biochemical and morphological responses of rat astrocytes to hydrogen peroxide-mediated cell death and to define the role that melatonin might… CONTINUE READING