Melatonin prevents apoptosis induced by UV-B treatment in U937 cell line.

  title={Melatonin prevents apoptosis induced by UV-B treatment in U937 cell line.},
  author={Francesca Luchetti and Barbara Canonico and Rosa Curci and Michela Battistelli and Ferdinando Mannello and Stefano Papa and Giorgio Tarzia and Elisabetta Falcieri},
  journal={Journal of pineal research},
  volume={40 2},
Melatonin influences circadian rhythms and acts as antioxidant and free radical scavenger. UV irradiation triggers multiple cellular events which lead to cell death, in particular to apoptosis; this process involves reactive oxygen species. Apoptotic machinery involves several pathways, in which mitochondria play crucial roles. In this work we have evaluated by means of cytometric, biochemical and ultrastructural approaches, if incubation of U937 promonocytic leukemia cells with melatonin may… CONTINUE READING


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