Melatonin potentiates the antiproliferative and pro-apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways.

@article{Wang2013MelatoninPT,
  title={Melatonin potentiates the antiproliferative and pro-apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways.},
  author={Jingshu Wang and Wei Guo and Wangbing Chen and Wendan Yu and Yun Tian and Lingyi Fu and Dingbo Shi and Bing Tong and Xiangsheng Xiao and Wenlin Huang and Wuguo Deng},
  journal={Journal of pineal research},
  year={2013},
  volume={54 4},
  pages={406-16}
}
Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is largely distributed in medical herbs and edible plants. Melatonin is an indoleamine compound produced in the pineal gland and also a plant-derived product. Both UA and melatonin have been shown to inhibit cancer cell growth in numerous studies, but they have never been combined altogether as an anticolon cancer treatment. In this study, we investigated whether the association between UA and melatonin leads to an enhanced… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 48 references

Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation

WG DENG, Y ZHU, WU KK.
J Biol Chem • 2003
View 4 Excerpts
Highly Influenced

Melatonin suppresses proinflammatory mediators in lipopolysaccharide - stimulated CRL 1999 cells via targeting MAPK , NF - kB , c / EBP b signal

D SHI
J Pineal Res • 2012

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