Melatonin potentiates rod signals to ON type bipolar cells in fish retina.

@article{Ping2008MelatoninPR,
  title={Melatonin potentiates rod signals to ON type bipolar cells in fish retina.},
  author={Yong Ping and Hai Huang and Xin-Jun Zhang and Xiong-Li Yang},
  journal={The Journal of physiology},
  year={2008},
  volume={586 11},
  pages={
          2683-94
        }
}
Melatonin is involved in regulation of a variety of physiological functions through activation of specific G-protein coupled receptors. However, the neuromodulatory role of melatonin, released from photoreceptors in the retina, is poorly understood. Here we show that melatonin enhances the sensitivity of the rod signal pathway by potentiating signal transfer from rod photoreceptors to ON bipolar cells (Rod-ON-BCs). Whole-cell patch-clamp recordings showed that melatonin induced a sustained… CONTINUE READING

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