Melatonin phase shifts human circadian rhythms in a placebo-controlled simulated night-work study.

@article{Sharkey2002MelatoninPS,
  title={Melatonin phase shifts human circadian rhythms in a placebo-controlled simulated night-work study.},
  author={Katherine M. Sharkey and Charmane I Eastman},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2002},
  volume={282 2},
  pages={R454-63}
}
There has been scant evidence for a phase-shifting effect of melatonin in shift-work or jet-lag protocols. This study tested whether melatonin can facilitate phase shifts in a simulated night-work protocol. Subjects (n = 32) slept in the afternoons/evenings before night work (a 7-h advance of the sleep schedule). They took melatonin (0.5 mg or 3.0 mg) or placebo before the first four of eight afternoon/evening sleep episodes at a time when melatonin has been shown to phase advance the circadian… CONTINUE READING
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