Melatonin membrane receptors in peripheral tissues: Distribution and functions

  title={Melatonin membrane receptors in peripheral tissues: Distribution and functions},
  author={Radomir M. Slominski and Russell J Reiter and Natalia Schlabritz-Loutsevitch and Rennolds S. Ostrom and Andrzej T Slominski},
  journal={Molecular and Cellular Endocrinology},
Many of melatonin's actions are mediated through interaction with the G-protein coupled membrane bound melatonin receptors type 1 and type 2 (MT1 and MT2, respectively) or, indirectly with nuclear orphan receptors from the RORα/RZR family. Melatonin also binds to the quinone reductase II enzyme, previously defined the MT3 receptor. Melatonin receptors are widely distributed in the body; herein we summarize their expression and actions in non-neural tissues. Several controversies still exist… CONTINUE READING
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