Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway.

@article{Song2017MelatoninmediatedUO,
  title={Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway.},
  author={Chao Song and Jiamin Zhao and Beibei Fu and Dan Li and Tingchao Mao and Wei Peng and Haibo Wu and Yong Zhang},
  journal={Free radical biology & medicine},
  year={2017},
  volume={112},
  pages={
          616-630
        }
}
Mitochondrial reactive oxygen species (ROS) production has been implicated in the pathogenesis of fluoride toxicity in liver. Melatonin, an indolamine synthesized in the pineal gland, was previously shown to protect against sodium fluoride (NaF)-induced hepatotoxicity. This study investigated the protective effects of melatonin pretreatment on NaF-induced hepatotoxicity and elucidates the potential mechanism of melatonin-mediated protection. Reducing mitochondrial ROS by melatonin substantially… CONTINUE READING
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