Melatonin is protective against MPTP-induced striatal and hippocampal lesions.

  title={Melatonin is protective against MPTP-induced striatal and hippocampal lesions.},
  author={Dar{\'i}o Acu{\~n}a-Castroviejo and Ana Coto-Montes and M Gaia Monti and Genaro G. Ortiz and Russell J Reiter},
  journal={Life sciences},
  volume={60 2},
The in vivo effect of melatonin on MPTP-induced neurotoxicity in mouse brain was studied. Melatonin (10 mg/kg) or saline was administered intraperitoneally (i.p.) to mice 30 min prior to a s.c. injection of MPTP (20 mg/kg). After MPTP treatment, the animals received melatonin or saline injections every hour for three hours. Mice were killed 4 hours after the MPTP injection. Regionally-specific increases in lipid peroxidation were observed in corpus striatum and hippocampus (71% and 58… CONTINUE READING


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