Melatonin inhibits proliferation and invasion via repression of miRNA-155 in glioma cells.

@article{Gu2017MelatoninIP,
  title={Melatonin inhibits proliferation and invasion via repression of miRNA-155 in glioma cells.},
  author={Junyi Gu and Zhongsheng Lu and Chenghong Ji and Yuchao Chen and Yuzhao Liu and Zhe Lei and Longqiang Wang and Hong-tao Zhang and Xiangdong Li},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2017},
  volume={93},
  pages={969-975}
}
Melatonin, an indolamine mostly synthesized in the pineal gland, exerts the anti-cancer effect by various mechanisms in glioma cells. Our previous study showed that miR-155 promoted glioma cell proliferation and invasion. However, the question of whether melatonin may inhibit glioma by regulating miRNAs has not yet been addressed. In this study, we found that melatonin (100μM, 1μM and 1nM) significantly inhibited the expression of miR-155 in human glioma cell lines U87, U373 and U251… CONTINUE READING

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