Melatonin inhibits nicotinic currents in cultured rat cerebellar granule neurons.

@article{Lax2008MelatoninIN,
  title={Melatonin inhibits nicotinic currents in cultured rat cerebellar granule neurons.},
  author={Pedro Lax},
  journal={Journal of pineal research},
  year={2008},
  volume={44 1},
  pages={70-7}
}
  • Pedro Lax
  • Published 2008 in Journal of pineal research
There is limited data regarding the effects of melatonin on the activity of neuronal acetylcholine receptors (nAChRs) themselves. This study analyzes the effects of low concentrations of melatonin on nicotine-evoked currents from cerebellar granule neurons (CGNs) in culture. Using electrophysiological and Ca(2+)-imaging techniques, it was found a subset of rat CGNs to which nicotine application elicited both intracellular Ca(2+) transients and inward whole-cell currents. These responses were… CONTINUE READING