Melatonin inhibits fatty acid-induced triglyceride accumulation in ROS17/2.8 cells: implications for osteoblast differentiation and osteoporosis.

@article{SanchezHidalgo2007MelatoninIF,
  title={Melatonin inhibits fatty acid-induced triglyceride accumulation in ROS17/2.8 cells: implications for osteoblast differentiation and osteoporosis.},
  author={Maria-Angeles Sanchez-Hidalgo and Zhao Hai Lu and D-X Tan and Mar{\'i}a Dolores Maldonado and Russel J. Reiter and Robert I. Gregerman},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2007},
  volume={292 6},
  pages={
          R2208-15
        }
}
Melatonin is produced not only by the pineal gland but by cells of the bone marrow. Moreover, melatonin is known to promote osteogenic differentiation in several cell line models and in multipotential bone marrow mesenchymal stem cells. Fatty acids have been independently shown to direct such cells to acquire the phenotype and molecular characteristics of adipocytes. To examine the effect of melatonin on intracellular triglyceride accumulation, an indicator of adipogenic differentiation in the… CONTINUE READING

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