Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity.

@article{Lin2016MelatoninIM,
  title={Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity.},
  author={Yung-Wei Lin and L M Lee and Wei-Jiunn Lee and Chih-Ying Chu and Peng Tan and Y Yang and Wei-Yu Chen and Shun-Fa Yang and Michael Hsiao and Ming-Hsien Chien},
  journal={Journal of pineal research},
  year={2016},
  volume={60 3},
  pages={277-90}
}
Renal cell carcinoma (RCC) is the most lethal of all urological malignancies because of its potent metastasis potential. Melatonin exerts multiple tumor-suppressing activities through antiproliferative, proapoptotic, and anti-angiogenic actions and has been tested in clinical trials. However, the antimetastastic effect of melatonin and its underlying mechanism in RCC are unclear. In this study, we demonstrated that melatonin at the pharmacologic concentration (0.5-2 mm) considerably reduced the… CONTINUE READING
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