Melatonin inhibits IL1β-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-κB activation.

  title={Melatonin inhibits IL1$\beta$-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-$\kappa$B activation.},
  author={Weiwei Qin and Wenbao Lu and Hongwei Li and Xiaochen Yuan and Bingwei Li and Qiuju Zhang and Ruijuan Xiu},
  journal={The Journal of endocrinology},
  volume={214 2},
Matrix metalloproteinases (MMPs) have been involved in inflammatory and degradative processes in pathologic conditions. The purpose of this study was to investigate the protective effect of melatonin in human umbilical vein endothelial cell (HUVEC) monolayer permeability and the regulation of MMP9 induced by interleukin 1β (IL1β (IL1B)) in HUVECs. Protection studies were carried out with melatonin, a well-known antioxidant and antiinflammatory molecule. MMP9 expression was increased with IL1… 

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