Melatonin inhibition of nicotine-stimulated dopamine release in PC12 cells.

  title={Melatonin inhibition of nicotine-stimulated dopamine release in PC12 cells.},
  author={Edward D Schiller and Thomas H. Champney and Cindy K Reiter and Douglas P. Dohrman},
  journal={Brain research},
  volume={966 1},
Melatonin, a pineal hormone, modifies numerous physiologic processes including circadian rhythms and sleep. In specific tissues, melatonin appears to have an inverse relationship with dopamine. To examine this relationship, a pheochromocytoma cell line (PC12) was used to determine the extent of melatonin's ability to inhibit nicotine-stimulated dopamine release. Multiple experiments were conducted that examined: (1). the dose response of acute melatonin (5 min); (2). the effects of chronic… CONTINUE READING

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