Melatonin induces mitochondrial-mediated apoptosis in human myeloid HL-60 cells.

@article{Bejarano2009MelatoninIM,
  title={Melatonin induces mitochondrial-mediated apoptosis in human myeloid HL-60 cells.},
  author={Ignacio Bejarano and Pedro Cosme Redondo and Javier Espino and Juan Antonio Rosado and Sergio D Paredes and Carmen Barriga and Russell J Reiter and Jos{\'e} Antonio Pariente and Ana Beatriz Rodr{\'i}guez},
  journal={Journal of pineal research},
  year={2009},
  volume={46 4},
  pages={392-400}
}
The role of melatonin in the mediation of apoptotic events has recently gained attention, especially after recent studies have reported that melatonin exerts antiapoptotic actions in normal cells but may activate proapoptotic pathways in some tumor cells. Here, we have evaluated the effect of melatonin on apoptosis in the human leukemia cell line HL-60. Melatonin treatment (1 mm) induced a significant increase in caspase-3 and -9 activities. The effect of melatonin on the activation of caspases… CONTINUE READING