Melatonin induces histone hyperacetylation in the rat brain.


We have reported that melatonin induces histone hyperacetylation in mouse neural stem cells, suggesting an epigenetic role for this pleiotropic hormone. To support such a role, it is necessary to demonstrate that melatonin produces similar effects in vivo. Histone acetylation, following chronic treatment with melatonin (4μg/ml in drinking water for 17 days… (More)
DOI: 10.1016/j.neulet.2013.01.050


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