Melatonin-induced inhibition of proliferation and G1/S cell cycle transition delay of human choriocarcinoma JAr cells: possible involvement of MT2 (MEL1B) receptor.

@article{Shiu1999MelatonininducedIO,
  title={Melatonin-induced inhibition of proliferation and G1/S cell cycle transition delay of human choriocarcinoma JAr cells: possible involvement of MT2 (MEL1B) receptor.},
  author={Stephen Yuen Wing Shiu and Leishi Li and Jiajie Xu and Celia Sook-Fun Pang and Jeffrey Tze-Fei Wong and Shiu Fun Pang},
  journal={Journal of pineal research},
  year={1999},
  volume={27 3},
  pages={183-92}
}
Melatonin, the pineal neurohormone, is an evolutionarily conserved photoperiodic signaling molecule with diverse functions that include the entrainment of human circadian rhythms. Although evidence supporting a direct inhibitory action of melatonin on human cancer cell proliferation exists in the literature, the molecular and cellular signaling mechanisms involved are largely undefined. In our study, significant inhibition of human choriocarcinoma JAr cell proliferation at physiological and… CONTINUE READING