Melatonin in type 2 diabetes mellitus and obesity

@article{Karamitri2018MelatoninIT,
  title={Melatonin in type 2 diabetes mellitus and obesity},
  author={Angeliki Karamitri and Ralf Jockers},
  journal={Nature Reviews Endocrinology},
  year={2018},
  volume={15},
  pages={105-125}
}
Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus (T2DM) remain two major challenges for public health systems globally. In the past 9 years, genome-wide association studies (GWAS) have established a major role for genetic variation within the MTNR1B locus in regulating fasting plasma levels of glucose and in affecting the risk of T2DM. This discovery generated a major interest in the melatonergic system, in particular the melatonin MT2 receptor (which is… CONTINUE READING

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