Melatonin in type 2 diabetes mellitus and obesity

  title={Melatonin in type 2 diabetes mellitus and obesity},
  author={Angeliki Karamitri and Ralf Jockers},
  journal={Nature Reviews Endocrinology},
Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus (T2DM) remain two major challenges for public health systems globally. In the past 9 years, genome-wide association studies (GWAS) have established a major role for genetic variation within the MTNR1B locus in regulating fasting plasma levels of glucose and in affecting the risk of T2DM. This discovery generated a major interest in the melatonergic system, in particular the melatonin MT2 receptor (which is… CONTINUE READING


Publications referenced by this paper.

Genome wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Beaumont, N R.
  • Hum. Mol. Genet
  • 2018

Macronutrientspecific effect of the MTNR1B genotype on lipid levels in response to 2 year weight loss diets

L Goni
  • J. Lipid Res
  • 2018

Meta-analysis on shift work and risks of specific obesity types.

  • Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2018

Metaanalysis on shift work and risks of specific obesity

M Sun
  • types. Obes. Rev
  • 2018