Melatonin in the treatment of fibromyalgia symptoms: A systematic review.

  title={Melatonin in the treatment of fibromyalgia symptoms: A systematic review.},
  author={Karim Hemati and Azade Amini Kadijani and Fatemeh Sayehmiri and Saeed Mehrzadi and Mozhdeh Zabihiyeganeh and Azam Hosseinzadeh and Alireza Mirzaei},
  journal={Complementary therapies in clinical practice},
Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
The findings suggest that oral melatonin plus zinc supplementation for 16 weeks is safe and potentially effective in reducing fatigue and improving the quality of life in ME/CFS.
Fibromyalgia and Associated Disorders: From Pain to Chronic Suffering, From Subjective Hypersensitivity to Hypersensitivity Syndrome
It is possible to define fibromyalgia as a cognitive disorder of cortical integration of chronic pain, with amplification of painful and sensory nociception, decrease in the threshold for the perception of pain, and persistence of a stimulus that maintains the process in chronicity.
Exploring Associations Between Metabolites and Symptoms of Fatigue, Depression and Pain in Women With Fibromyalgia
The preliminary data presented suggest that metabolites representing energy, amino acid, or lipid classification may be associated with pain symptom severity and interference in women with FM.
Sleeping is a nightmare: A qualitative study on the experience and management of poor sleep quality in women with fibromyalgia.
Women with FM recognize that they need to receive more information from nurses and allied professions about sleep in the context of FM and how to effectively manage poor sleep quality.
Mitochondria and immunity in chronic fatigue syndrome
  • G. Anderson, M. Maes
  • Biology, Medicine
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2020
Clinical Application of Melatonin in the Treatment of Cardiovascular Diseases: Current Evidence and New Insights into the Cardioprotective and Cardiotherapeutic Properties
This review aims to summarize current findings of melatonin treatment for CVDs, an anti-inflammatory and antioxidant agent with a wide range of therapeutic properties, focusing on mechanistic pathways.
Current Concepts Review: Relevance of Sleep Disturbances to Orthopaedic Surgery: A Current Concepts Narrative and Practical Review.
Poor sleep can lead to worse outcomes after fracture, such as chronic pain and delayed recovery, and Orthopaedic surgeons can play an important role in the screening of sleep disorders among their patients.
Paying Attention to Circadian Rhythms in the Treatment of COVID-19
Key findings that show a link between circadian rhythms and viral infection are explored and could be helpful for clinical and preclinical studies to discover a useful and highly effective treatment for eradicating the COVID-19 disease.


Adjuvant use of melatonin for treatment of fibromyalgia
Administration of melatonin, alone or in a combination with fluoxetine, was effective in the treatment of patients with FMS.
The Effect of Melatonin in Patients with Fibromyalgia: A Pilot Study
The preliminary results suggest that melatonin can be an alternative and safe treatment for patients with FM and double-blind placebo controlled studies are needed.
Duloxetine for the management of fibromyalgia syndrome
Duloxetine has proven efficacy in managing pain and mood symptoms in adult FMS patients with and without major depressive disorder, but must be used with caution in patients with fatigue, insomnia, gastrointestinal complaints, headache, cardiovascular disease, bleeding-risk, and in those 24 years of age and younger due to risk of suicidality.
Fibromyalgia: a clinical review.
Fibromyalgia may be considered as a discrete diagnosis or as a constellation of symptoms characterized by central nervous system pain amplification with concomitant fatigue, memory problems, and sleep and mood disturbances.
The involvement of melatonin in the clinical status of patients with fibromyalgia syndrome.
The results of this study may suggest that changes in melatonin levels when associated with other neuroimmunoendocrine changes may impact directly and negatively on the manifestation of symptoms that make up the clinical picture of FM.
Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial
It is suggested that vitamin D supplementation has significant therapeutic benefits in the management of FMS, especially in pain reduction of patients with fibromyalgia.
Understanding fibromyalgia and its related disorders.
  • D. Goldenberg
  • Medicine, Psychology
    Primary care companion to the Journal of clinical psychiatry
  • 2008
Primary care physicians should consider the psychosocial as well as the physiologic aspects of fibromyalgia and its related disorders to provide patients with a comprehensive treatment plan that includes pharmacologic and nonpharmacologic treatment options.
Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial
Melatonin alone and in combination increased the inhibitory PMS as assessed by the Numerical Pain Scale [NPS(0-10)] reduction during the CPM-TASK, and increased the inhibition of the endogenous pain-modulating system.
Duloxetine for the treatment of fibromyalgia
This article presents a brief review of the physiologic abnormalities seen in fibromyalgia, current theories of widespread pain, and treatment options, including emerging therapeutics, with a focus