Melatonin in the skin: synthesis, metabolism and functions.

  title={Melatonin in the skin: synthesis, metabolism and functions.},
  author={Andrzej T Slominski and Desmond J. Tobin and Michal A Żmijewski and Jacobo Wortsman and Ralf Paus},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={19 1},
Melatonin, a ubiquitous methoxyindole, is produced by and metabolized in the skin. Melatonin affects skin functions and structures through actions mediated by cell-surface and putative-nuclear receptors expressed in skin cells. Melatonin has both receptor-dependent and receptor-independent effects that protect against oxidative stress and can attenuate ultraviolet radiation-induced damage. The widespread expression and pleiotropic activity of the cutaneous melatoninergic system provides for a… CONTINUE READING
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