Melatonin in autism spectrum disorders: a systematic review and meta‐analysis

  title={Melatonin in autism spectrum disorders: a systematic review and meta‐analysis},
  author={Daniel A Rossignol and Richard Eugene Frye},
  journal={Developmental Medicine \& Child Neurology},
  • D. Rossignol, R. Frye
  • Published 1 September 2011
  • Medicine, Psychology, Biology
  • Developmental Medicine & Child Neurology
Aim  The aim of this study was to investigate melatonin‐related findings in autism spectrum disorders (ASD), including autistic disorder, Asperger syndrome, Rett syndrome, and pervasive developmental disorders, not otherwise specified. 
Melatonin: an option for managing sleep disorders in children with autism spectrum disorder.
Sleep disorders arise from a variety of causes and are thought to affect 20–30% of typically developing (i.e., non-special-needs) children.[1][1] This frequency increases to up to 80% in children
Meta‐analysing the effectiveness of melatonin for sleep‐disturbed individuals with autism spectrum conditions: should Rett syndrome be included?
It is believed that autism spectrum conditions and Rett syndrome should be considered separately in sleep studies, and therefore that the data collected in Rett Syndrome should not be included in a meta-analysis of melatonin effects on sleep in individuals with ASD.
Autism spectrum disorder: advances in evidence-based practice
It is important to note that not all people with ASD identify their challenges as a disorder, so it is not necessary to diagnose them as having a specific disorder.
Autism Spectrum Disorder and Sleep.
Focus on Autism and Related Conditions.
The current understanding of autism spectrum disorder is examined, which includes estimates of prevalence, discussion of etiology, and current and evolving treatments.
Systematic review and guide to management of core and psychiatric symptoms in youth with autism
This review evaluates treatment evidence for six common symptom targets in children/adolescents with ASD and provides a resource to facilitate application of the evidence to clinical practice.
Sleep in Autism
The authors discuss the etiology and manifestations of sleep disorders in children with ASD, as well as their clinical evaluation and treatment options.
Pharmacotherapy in autism spectrum disorder
ASD is a complex and heterogeneous disorder which is defined by the constellation of impairment in reciprocal social interactions, functional communication skills, and the presence of repetitive and
Pharmacological Approach to Sleep Disturbances in Autism Spectrum Disorders with Psychiatric Comorbidities: A Literature Review
There is limited evidence for psychopharmacological treatments in autism; however, these are frequently prescribed and Melatonin, antipsychotics, antidepressants, and α agonists have generally been used with melatonin, having a relatively large body of evidence.
Evaluation of drug interventions for the treatment of sleep disorders in children with autism spectrum disorders: a systematic review
Melatonin appears to be useful for the treatment of sleep problems in patients with ASD, but further studies are needed to determine the effects of other drugs.