Melatonin improves sleep and reduces nitrite in the exhaled breath condensate in cystic fibrosis--a randomized, double-blind placebo-controlled study.

@article{CastroSilva2010MelatoninIS,
  title={Melatonin improves sleep and reduces nitrite in the exhaled breath condensate in cystic fibrosis--a randomized, double-blind placebo-controlled study.},
  author={Claudia de Castro-Silva and Veralice Meireles Sales de Bruin and Geanne M. A. Cunha and Deuzilane Muniz Nunes and Camila Andrade Mendes Medeiros and Pedro Felipe Carvalhedo de Bruin},
  journal={Journal of pineal research},
  year={2010},
  volume={48 1},
  pages={
          65-71
        }
}
Cystic fibrosis (CF) is a chronic progressive disorder characterized by repeated episodes of respiratory infection. Impaired sleep is common in CF leading to reduced quality of life. Melatonin, a secretory product of the pineal gland, has an important function in the synchronization of circadian rhythms, including the sleep-wake cycle, and has been shown to possess significant anti-oxidant properties. To evaluate the effects of exogenous melatonin on sleep and inflammation and oxidative stress… CONTINUE READING

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