Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8)

@article{Cuesta2010MelatoninII,
  title={Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8)},
  author={Sara Cuesta and Roman A. Kireev and Katherine Forman and Cruz Garc{\'i}a and Germaine Escames and Carmen Ariznavarreta and Elena Vara and Jes{\'u}s A. F. Tresguerres},
  journal={Experimental Gerontology},
  year={2010},
  volume={45},
  pages={950-956}
}

Figures and Tables from this paper

Effect of growth hormone treatment on pancreatic inflammation, oxidative stress, and apoptosis related to aging in SAMP8 mice.
TLDR
Results indicate that aging is associated with significant alterations in the relative expression of pancreatic genes involved in inflammation, oxidative stress, and apoptosis and GH administration to old SAMP8 mice was able to improve pancreas from this parameters.
Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-accelerated mouse prone 8
TLDR
Interestingly, impaired stress response and increased inflammation in SAMP8 mice were associated with elevated concentrations of ascorbic acid and α-tocopherol in the liver.
Effect of a combined treatment with growth hormone and melatonin in the cardiological aging on male SAMP8 mice.
TLDR
The results supported the existence of a proapoptotic and oxidative status together with inflammatory processes in the heart of old mice, with increases of inflammatory cytokines, caspase activity, HO-1, BAX,NFkBp50, and NFkBp52 and decreases of eNOS and Bcl2.
Dietary Animal Plasma Proteins Improve the Intestinal Immune Response in Senescent Mice
TLDR
Results indicate that senescent mice have an impaired mucosal immune response characterized by unspecific GALT activation and a weak specific immune response, which can be prevented by dietary supplementation with spray-dried animal plasma.
Ginsenoside Rg1 ameliorates aging-induced liver fibrosis by inhibiting the NOX4/NLRP3 inflammasome in SAMP8 mice
TLDR
The findings of the present study suggested that Rg1 may attenuate aging-induced liver injury and fibrosis by reducing NOX4-mediated ROS oxidative stress and inhibiting NLRP3 inflammasome activation.
Beneficial effect of melatonin treatment on age-related insulin resistance and on the development of type 2 diabetes
TLDR
Melatonin administration was able to reduce oxidative stress and inflammation and thus to improve pancreatic function in old mice, and insulin resistance is diminished and plasma insulin is reduced, enhancing insulin pancreatic content and reducing plasma glucose levels and HOMA index.
Protective actions of melatonin and growth hormone on the aged cardiovascular system
TLDR
This paper summarizes a set of studies related to the potential role that therapy with GH and melatonin may play in the protection of the altered cardiac function due to aging, with a focus on experiments performed using the senescence-accelerated mouse as an aging model.
The Melatonin Receptor MT2 Is Partly Involved in the Anti-Inflammatory Effects of Melatonin in Rats With Type 2 Diabetes Mellitus
TLDR
Melatonin significantly reduced increased blood levels of liver transaminases (AST, ALT) and blood urea nitrogen (BUN) in diabetic rats and the MT2 receptor was only partly involved in the anti-inflammatory effects of melatonin.
...
...

References

SHOWING 1-10 OF 58 REFERENCES
Cardiological aging in SAM model: effect of chronic treatment with growth hormone
TLDR
The results suggest that inflammation, apoptosis and oxidative stress could play an important role in the observed cardiovascular alterations related to aging of SAM-P8 mice and that GH may play a potential protective effect on the cardiovascular system of these animals.
Melatonin is able to prevent the liver of old castrated female rats from oxidative and pro‐inflammatory damage
TLDR
Investigation of the effect of aging and ovariectomy on various physiological parameters related to inflammation and oxidative stress in livers obtained from old female rats found that administration of melatonin significantly reduced NOx, LPO levels and pro‐inflammatory cytokines in the liver as compared with untreated rats.
Effect of melatonin administration on parameters related to oxidative damage in hepatocytes isolated from old Wistar rats
TLDR
Melatonin administration seems to exert beneficial effects against age‐induced changes in hepatocytes, which induces changes in several organs and tissues, such as the liver, and this process might be due to oxidative damage caused by free radicals and inflammatory mediators.
Melatonin modulates signal transduction pathways and apoptosis in experimental colitis
TLDR
Results of this study show that melatonin administration exerts beneficial effects in inflammatory bowel disease by modulating signal transduction pathways.
Hormonal regulation of pro-inflammatory and lipid peroxidation processes in liver of old ovariectomized female rats
TLDR
Investigation of the effect of aging and ovariectomy on various physiological parameters related to inflammation and oxidative stress in livers obtained from old female rats found that hormonal replacement therapies was able to inhibit the induction of pro-inflammatory cytokines and iNOS, decreased the levels of oxidative stress markers and had therapeutic potential in the prevention of liver injury.
Heme oxygenase 1 expression in rat liver during ageing and ethanol intoxication
TLDR
The finding that HO-1 expression did not increase progressively during ageing may be explained by a decreased transcriptional ability to respond to stress in older animals, rather than by a reduction in oxidative stress.
Effect of chronic treatments with GH, melatonin, estrogens, and phytoestrogens on oxidative stress parameters in liver from aged female rats
TLDR
The administration of GH, melatonin, Eos and Phyt to castrated females seem to reduce oxidative changes in the liver from old ovariectomized rats.
Modulation of apolipoprotein E and interleukin-1β in the aging liver
Melatonin: An Established Antioxidant Worthy of Use in Clinical Trials
TLDR
Melatonin is a multifunctional indolamine that counteracts virtually all pathophysiologic steps and displays significant beneficial actions against peroxynitrite-induced cellular toxicity, related to melatonin’s antioxidative and antiinflammatory properties.
...
...