Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis

  title={Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis},
  author={Ibtihal Siddiq Abdelgadir and Morris Gordon and Anthony K Akobeng},
  journal={Archives of Disease in Childhood},
  pages={1155 - 1162}
Importance Children with neurodevelopmental disorders have a higher prevalence of sleep disturbances. Currently there is variation in the use of melatonin; hence, an up-to-date systematic review is indicated to summarise the current available evidence. Objective To determine the efficacy and safety of melatonin as therapy for sleep problems in children with neurodevelopmental disorders. Data sources and study selections PubMed, Embase, the Cumulative Index to Nursing and Allied Health… 
Adverse Events Associated with Melatonin for the Treatment of Primary or Secondary Sleep Disorders: A Systematic Review
There are insufficient robust data to allow a meaningful appraisal of concerns that melatonin may result in more clinically significant adverse effects in potentially at-risk populations, and the scarcity of evidence from long-term RCTs limits the conclusions regarding the safety of continuous melatonin therapy over extended periods.
Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders
Long-term melatonin treatment in combination with adequate sleep hygiene interventions may afford clinical benefits to children with NDDs and potentially elevates their well-being.
Effect of melatonin in children with neurodevelopmental disabilities and sleep disorders
Melatonin had a significant impact on total sleep time and quality during the pre and post assessment of children with neurodevelopmental disabilities and sleep disorders.
The use and misuse of exogenous melatonin in the treatment of sleep disorders
  • R. Riha
  • Medicine, Psychology
    Current opinion in pulmonary medicine
  • 2018
There is evidence for the efficacy of melatonin in the management of insomnia and some intrinsic disorders of circadian rhythm in adults and children as well as in reducing sleep onset latency in jet-lag and shift work disorder in adults.
Pediatric sleep disturbances and treatment with melatonin
Melatonin can be safe and effective in treating both primary sleep disorders and the sleep disorders associated with various neurological conditions, however, there is a need for further studies aimed at identifying the sleep disordered infants and children who will benefit most from melatonin treatment, and determining appropriate doses based on the severity and type of disorder.
Melatonin use for sleep disturbance in children with cerebral palsy: a narrative review
Due to the variance in the product, minimal number of studies, adverse effect potential, and lack of data on doses in children, melatonin should be used with caution in children with cerebral palsy.
Pharmacotherapeutic management of sleep disorders in children with neurodevelopmental disorders
This narrative review, the authors highlight and summarize the most common drugs and supplements used for the treatment of sleep problems in children with neurodevelopmental disabilities and recommend the use of melatonin and melatonin receptor agonists, sedating antidepressants, antipsychotics, antihistamines, gabapentin, clonidine and orexin receptor antagonists, and benzodiazepines and hypnotic Benzodiazepine receptor agonist.
Regulatory aspects and evidences of melatonin use for sleep disorders and insomnia: an integrative review.
According to the evidences found, it did not demonstrate toxicity or severe side effects, nor dependence even when administered at high doses, suggesting that it is a safe medication to treat patients of different ages suffering from sleeping disorders.


Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment.
Despite the extremely limited randomized clinical trial data, melatonin appears to remain a commonly prescribed drug for disturbed sleep in children with neurodevelopmental abnormalities.
The use of MElatonin in children with neurodevelopmental disorders and impaired sleep: a randomised, double-blind, placebo-controlled, parallel study (MENDS).
Melatonin is effective in reducing SOL in children with neurodevelopmental delay by a mean of 45 minutes; a value of 30 minutes was specified a priori to be clinically important and will be published in full in Health Technology Assessment.
Melatonin for Treatment of Sleep Disorders in Children With Developmental Disabilities
The greater the sleep latency was at baseline or when receiving placebo, the more pronounced was the decrease in sleep latency with melatonin, suggesting that synthetic melatonin reduces sleep latency in children with developmental disabilities.
Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta‐analysis
A meta‐analysis of placebo‐controlled randomized trials of melatonin in individuals with intellectual disabilities and sleep problems showed that melatonin treatment decreased sleep latency, increased total sleep time, and significantly decreased the number of wakes per night.
Melatonin Treatment for Insomnia in Pediatric Patients with Attention-Deficit/Hyperactivity Disorder
It is suggested that melatonin is a well-tolerated and efficacious treatment option for pediatric patients with chronic SOI and ADHD and Regulated melatonin products and larger, well-designed trials to establish optimal dosing regimens and long-term safety are needed.
Current role of melatonin in pediatric neurology: clinical recommendations.
Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia.
Combined sleep hygiene and melatonin was a safe and effective treatment for initial insomnia in children with ADHD taking stimulant medication.
Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia.
Melatonin advanced circadian rhythms of sleep-wake and endogenous melatonin and enhanced total time asleep in children with ADHD and chronic sleep onset insomnia; however, no effect was found on problem behavior, cognitive performance, or quality of life.