Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes.

  title={Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes.},
  author={B A Malow and Karen W Adkins and Susan G. McGrew and Lily Wang and Suzanne E. Goldman and Diane B Fawkes and Courtney P. Burnette},
  journal={Journal of autism and developmental disorders},
  volume={42 8},
  pages={1729-37; author reply 1738}
Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD). Twenty-four children, free of psychotropic medications, completed an open-label dose-escalation study to assess dose-response, tolerability, safety, feasibility of collecting actigraphy data, and ability of outcome measures to detect change during a 14-week intervention. Supplemental melatonin improved sleep latency, as measured by actigraphy, in most children at 1 or 3 mg… CONTINUE READING
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